Fecha de publicación: -- Fuente: PubMed "olive oil" Endocr Metab Immune Disord Drug Targets. 2026 Sep 25. doi: 10.2174/0118715303480002260921081812. Online ahead of print.ABSTRACTINTRODUCTION: The Mediterranean and the Japanese diets are followed worldwide as healthy dietary patterns. Both are listed as the intangible cultural heritage of humanity by UNESCO. This systematic review differentiates the two diets in relation to anti-aging, identifying similarities and differences, and considers healthy dietary methods.METHODS: The keywords employed in the systematic review were "Mediterranean diet", "Japanese diet", "aging" and "anti-aging," and a PubMed search was conducted. This research conforms to the Cochrane guidelines and observes Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA).RESULTS: One-third of the mortality rate from cardiovascular diseases has been observed in the Mediterranean countries, such as Italy and Greece, in comparison to American and North European countries. The Mediterranean diet is considered healthy, as its health benefits have been closely associated with the dietary habits of the people. Both the Mediterranean and Japanese diets are low in fat, sugar, and calories. These people consume large amounts of vegetables, legumes, fish, and grains daily. These dietary habits may help reduce the risk of chronic inflammation-associated diseases such as cardiovascular diseases, metabolic syndrome, and obesity, which are linked to reduced life expectancy.DISCUSSION: The Mediterranean diet includes large amounts of extra-virgin olive oil and dairy products, with limited consumption of meat and other sources of fat. The Japanese diet includes large amounts of fermented foods and seaweed. High consumption of phytochemicals, particularly polyphenols, is a common feature of both dietary patterns. Japanese people are familiar with the concept of "ME-BYO," which focuses on identifying health conditions that fall between health and disease and addressing them before disease onset. This approach may contribute to health and longevity, as Japan has one of the highest life expectancies in the world.CONCLUSION: The Mediterranean-style Japanese diet, a well-balanced diet, reduces the various disease risks by protecting us from the onset of chronic inflammation. This dietary method is recommended for the prevention of "ME-BYO," is suitable for anti-aging, and might contribute to a healthy and long life not only for Japanese people but also for people living worldwide.PMID:42813622 | DOI:10.2174/0118715303480002260921081812