Fuente: PubMed "olive oil" Biomolecules. 2026 Apr 30;16(5):666. doi: 10.3390/biom16050666.ABSTRACTThis study aimed to evaluate the effects of several minor components of extra virgin olive oil (EVOO) on platelet thromboxane and vascular prostacyclin production in rat aortic rings under high-glucose conditions (300 mg/dL), in relation to their potential antioxidant actions. Under hyperglycaemic conditions, thromboxane production was 1.3 times higher, while prostacyclin production was 40.9% lower than in samples with 100 mg/dL glucose in aortic rings, accompanied by marked oxidative stress (65.6% higher than in samples with 100 mg/dL glucose). The compounds tested inhibited thromboxane production in a concentration-dependent manner, with relative potencies (secoiridoid derivatives (IC50 range: 10-6 M) = triterpenes (10-6 M) > alcoholic phenols (10-5 M for hydroxytyrosol and 10-4 M for the rest)), while preserving prostacyclin production (5-20% inhibition). All compounds also exerted vascular antioxidant effects, reducing oxidative stress markers and enhancing antioxidant parameters (IC50 range: 10-6-10-5 M), and these effects were observed under both normoglycaemic (100 mg/dL) and hyperglycaemic (300 mg/dL) conditions.PMID:42194016 | PMC:PMC13204358 | DOI:10.3390/biom16050666