Fecha de publicación: 12/11/2024 Fuente: PubMed "olive oil" Food Chem. 2024 Oct 28;464(Pt 3):141811. doi: 10.1016/j.foodchem.2024.141811. Online ahead of print.ABSTRACTXanthophylls lutein and zeaxanthin are carotenoids with important antioxidant capacities and relevant roles against the prevention of eye diseases. In this study a valorization of non-commercial spinach to obtain lutein and zeaxanthin as raw materials to develop nutraceuticals was carried out. Three oil matrixes were analyzed: extra virgin olive oil (EVOO), lutein and zeaxanthin enriched EVOO (EVOO+LZ), and EVOO enriched with 25 % of EVOO+LZ (namely EVOO+D) to evaluate their biological potential as antioxidants. Urinary antioxidant total capacity, and circulatory blood levels of lutein and zeaxanthin were determined (in vivo analysis). Also, a simulation of gastrointestinal simulation (in vitro analysis) was performed. The results showed an increase in the circulatory levels of lutein-zeaxanthin after the ingestion of EVOO+LZ during 45 and 60 days, and an increase in the urinary antioxidant levels after the intake of EVOO+LZ and EVOO+D. In vitro assay revealed that both xanthophylls showed bioavailability to be assimilated in the intestinal tract. Therefore, these EVOO enriched with lutein-zeaxanthin might be considered as powerful antioxidant tools with potential properties in the management/prevention of eye diseases.PMID:39532059 | DOI:10.1016/j.foodchem.2024.141811