Fuente: PubMed "olive oil" RSC Adv. 2026 Jul 7. doi: 10.1039/d6ra00708b. Online ahead of print.ABSTRACTOlea europaea L. (olive tree) stands as an enduring emblem of Mediterranean culture and a treasure trove of structurally diverse phytochemicals with profound biological potential. This review presents a structured, data-driven overview of over 300 metabolites previously reported across various olive sources, including leaves, fruits, olive oil, pomace, flowers, etc. These compounds are systematically classified into 15 chemical classes, each described through its basic skeleton and position numbering, highlighting structural features that allow clear differentiation between closely related compounds. Secoiridoids emerge as the dominant class, with oleuropein and ligustroside serving as key representatives, and biosynthetic intermediates such as tyrosol, hydroxytyrosol, and elenolic acid playing central roles. The distribution of metabolites across organs revealed that leaves represent the most abundant source, followed by fruits and olive oil, while pomace also contained a considerable amount, emphasizing its potential value as a by-product for future exploitation. For each metabolite, comprehensive chemical identifiers (PubChem ID, SMILES, InChI, formula, and exact mass) and, for the first time, an analytical confidence level (validated via a five-level scoring system) are provided in the SI. This analysis reveals a predominance of moderately validated compounds (Level 3), highlighting a critical need for further structural elucidation. Collectively, this robust and cheminformatics-ready dataset serves as an accessible resource, poised to accelerate future studies in virtual screening, molecular docking, and network pharmacology. It also critically guides efforts to expand structural validation for low-confidence compounds and encourages exploration of underrepresented organs, thereby significantly enriching the landscape of therapeutic mapping. Additionally, this review integrates recent insights into isolation yields, impurity profiles, and toxicological aspects of Olea europaea metabolites, thereby providing a holistic framework for their therapeutic evaluation and safe exploitation.PMID:42416725 | PMC:PMC13338935 | DOI:10.1039/d6ra00708b