Fecha de publicación: 28/12/2021 Fuente: Wipo "olive oil" The invention discloses a lignan compound, a preparation method and application thereof, and relates to the field of natural medicines. The compound is named as (8-(2, 3-dihydroxy-4-methoxybenzyl)-8'-(4'-hydroxy-3'-methoxybenzyl) butyrolactone). The preparation method is that the lignan compound is separated and extracted from aSyringa oblata Lindl medicinal material. The invention also discloses application of the compound in preparation of drugs for treating acute liver injury, wherein the compound can obviously reducetransaminase of a CCl4-olive oil induced chemical liver injury model rat and increase the content of superoxide dismutase and glutathione in rat serum, and is obvious in the effect of preventing and treating chemical liver injury.