Fecha de publicación: 07/10/2022 Fuente: Wipo "olive oil" Amlodipine Basylate is employed to treat high blood pressure and prevents calcium ions from penetrating the cardiac and vascular mucosal tissue through transmembrane pathways. It was selected for synthesis because it satisfies all physicochemical criteria necessary for skin penetration. Olive oil has been demonstrated to be the much more efficient oil since it has penetrating properties and improves the stiffness of a patches during formulation. The drug's solubility, melting point, partition coefficient, and pH preformulation experiments were determined to be comparable to the norm. The solvent casting method was used to create the transdermal films for amlodipine, and various evaluation criteria, including weight variation, thickness, folding endurance, drug content, percentage moisture absorption, percentage moisture loss, and diffusion studies, were used to gauge their effectiveness. All of the parameters that the formulae indicated were within acceptable bounds. The optimal • formulation for amlodipine besylate was formulation F5, which contained olive oil and demonstrated greater release (98.89%) over a long enough time—up to 72 hours.