Fecha de publicación: 27/05/2022
Fuente: Wipo "olive oil"
The present disclosure is related to the emulsion of Saffron aqueous extract, olive oil and coenzyme Q10 (CoQ10). The emulsion was prepared by dry gum method and evaluated against an antineoplastic doxorubicin that causes cardio toxicity in rats. The prepared emulsion was stable thermodynamically. The pharmacological activity of emulsion in doxorubicin treated rats indicated better AST, ALT, LDH, creatinine, lipid profile (HDL, TC, LDL, VLDL and TG), SOD, catalase and GSH. The heart weight which was enhanced because of doxorubicin treatment was also reduced b invented emulsion. The inventive emulsion also showed cardio protection against doxorubicin induced toxicity as it regularizes enzymes, lipids and oxidants expressions.