Fuente: WIPO "olive oil" The present invention relates to reverse micelle system comprising sterol, acylglycerol, alcohol, water, water-soluble active ingredient, phospholipid or sphingolipid, wherein the weight ratio phospholipid or sphingolipid/acylglycerol range from 0.05 to 0.55 and a further vegetable oil. The invention also relates to the preparation method of said reverse micelle system, their use and pharmaceutical composition comprising the same.