A system and method for computer vision assisted physical-labels functions to use functional, large format product labeling for better computer vision (CV) identification. The product labels and detection capabilities of the system and method enhance product label detection and interpretation for use with image sensing at a distance. The product labels are non-obtrusive and can mitigate changes to sizing or visual appearance of packaging of goods or products. The system and method can enable universal product labeling for vision-based commerce and other applications.