Fecha de publicación: 05/01/2023 Fuente: Wipo Milk or dairy products The present disclosure relates to methods and products for reducing side effects associated with immunotherapy using immune agonist antibodies. In certain embodiments, the present disclosure provides a method of reducing one or more side effects associated with immunotherapy using an immune agonist antibody alone, or in combination with an immune checkpoint inhibitor, in a subject suffering from a cancer, the method comprising modifying the gut microbiota in the subject and thereby reducing the one or more side effects associated with the immunotherapy in the subject.