Fuente: WIPO "milk" A culture device having a substrate and a circulating flow guiding chamber for culturing microbial cells such as animal or plant cells, in which a base material made from fibrous substance, ceramic, or porous resin, having a large number of spaces through which culture medium passes, and being capable of adhering or immobilising microorganisms is placed in a lidded vessel, and a rotating means of the circulating flow guiding chamber circulates culture medium. The culture medium undergoes gas exchange in the upper space of the vessel during the circulation. The growth and maintenance of a large quantity of microbial cells at high density are possible.