Fecha de publicación: 06/09/2022 Fuente: WIPO Wine The invention relates to the field of daily cosmetics, and particularly discloses bacillus amyloliquefaciens BA-1, a lysate, a preparation method of the lysate, application of the lysate in cosmetics and face cream. The bacillus amyloliquefaciens BA-1 is separated from yellow rice wine yeast and is preserved in the China General Microbiological Culture Collection Center (CGMCC) on August 9, 2021, and the preservation number is CGMCC No.23132. The bacillus amyloliquefaciens BA-1 has the advantages that the bacillus amyloliquefaciens BA-1 can be used for preparing yellow rice wine yeast; the bacillus amyloliquefaciens BA-1 is used for preparing the lysate, the lysate is high in safety, the number of various antioxidants and antioxidant enzymes in the body can be increased, the number of active oxygen and peroxide can be reduced respectively, the possibility of oxidative stress damage of cells can be reduced, the cells can be effectively protected, and the lysate has a good application prospect. And apoptosis and aging of cells are delayed. The lysate is used in cosmetics, has no irritation to human skin, and has the effects of moisturizing, nourishing, repairing barriers, tightening skin and the like.