Fecha de publicación: 22/12/2024 Fuente: PubMed "Tomato process" Plant Commun. 2024 Dec 20:101229. doi: 10.1016/j.xplc.2024.101229. Online ahead of print.ABSTRACTEpitranscriptomic chemical modifications of RNAs have emerged as potent regulatory mechanisms in the plant stress adaptation process. Currently, over 170 distinct chemical modifications have been identified in mRNAs, tRNAs, rRNAs, microRNAs (miRNAs), and long-noncoding RNAs (lncRNAs). The genetic and molecular studies have identified the genes responsible for adding and removing chemical modifications on RNA molecules, known as "writers" and "erasers," respectively. Among the identified chemical modifications in mRNAs, N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNAs. Recent studies have identified m6A writers and erasers across different plant species, including Arabidopsis (Arabidopsis thaliana), rice (Oryza sativa), cotton (Gossypium hirsutum), and tomato (Solanum lycopersicum). Accumulating discoveries have improved our understanding of the functions of RNA modifications in plant stress responses. This review highlights the latest developments in RNA modification research, emphasizing the biological and cellular roles of diverse chemical modifications in mRNAs, tRNAs, rRNAs, miRNAs, and lncRNAs in the plant response to environmental and hormonal signals. Moreover, we propose and discuss the critical questions and future challenges in enhancing our understanding of the cellular and mechanistic roles of RNA modifications in plant stress responses. Integrating molecular insights regarding the regulatory roles of RNA modifications in stress responses with novel genome- and RNA-editing technologies will facilitate the breeding of stress-tolerant crops via precise engineering of RNA modifications.PMID:39709520 | DOI:10.1016/j.xplc.2024.101229