Fuente:
WIPO "tomato"
The present disclosure is a nucleic acid delivery construct used for treatment of a hematologic malignancy, the nucleic acid delivery construct having an assembly structure in which a nucleic acid analog represented by the following formula (1) and a nucleic acid to be delivered containing a microRNA that regulates a network of the oncogene KRAS are assembled with each other through electrostatic interaction. Wherein N represents a cationic artificial nucleic acid, H represents a hydrophilic polymer, S1 represents a spacer 1, S2 represents a spacer 2, and L represents a ligand; N has structural units in which a base is bonded to a hexose selected from ribose and deoxyribose, linking structures linking two of the structural units, and a backbone structure having cationic groups; and the cationic artificial nucleic acid is capable of assembling through electrostatic interaction between a phosphate group of the nucleic acid to be delivered and the cationic group.