Fecha de publicación: -- Fuente: WIPO "tomato" This disclosure provides methods, compositions, and formulations for treating, preventing, or reducing allergic reactions — including anaphylaxis — and mast cell-mediated disorders. Methods include administering to a subject a therapeutically effective amount of a focal adhesion kinase (FAK) pathway modifier, including small molecule FAK inhibitors, FAK-targeting proteolysis-targeting chimeras (PROTACs), and nucleic acid-based FAK expression modulators.