Fecha de publicación: -- Fuente: WIPO "tomato" Disclosed are synthetic lipids comprising a headgroup derived from a central nervous system (CNS)‑active small molecule covalently linked through a linker to at least one lipid tail. The synthetic lipids may assemble into lipid nanoparticles (LNPs). Methods of making the LNPs, delivering polynucleotides to brain cells, enabling gene editing, and treating CNS disorders are also provided.