Fuente: WIPO "tomato" The present disclosure concerns genetic modification of fibroblasts or fibroblast-derived materials (including of the fibroblasts from which the fibroblast-derived materials are derived). In specific aspects, they are modified such that they may express one or more surface markers that allow targeting to a tissue and/or organ of interest. In some aspects, they are modified such that they may lose one or more surface markers that then allow targeting to a tissue and/or organ of interest. In certain aspects, one or more surface markers are modified that then allows targeting to a tissue and/or organ of interest.