Fuente: WIPO "tomato" The present invention relates to computer implemented methods for identifying enhancer elements, the method comprising: (a) receiving a first candidate sequence; (b) generating candidate sequences sequence using single base pair saturation mutagenesis; (c) for each promoter sequence generating a plurality of input sequences, each comprising a candidate sequence and the promoter sequence; (d) inputting the input sequences into two or more machine learning models; (e) receiving a predicted chromatin accessibility measurement for each input sequence from the two or more machine learning models; (f) synthesizing a composite measurement for each candidate sequence (g) selecting a top performing sequence; and (h) if the top performing sequence matches the first candidate sequence, identifying the top performing sequence as the enhancer element in the plant, and if the top performing sequence does not match the first candidate sequence, updating the top performing sequence and repeating steps (b) – (g).