Fuente: WIPO "tomato" Disclosed herein are methods for producing interfering RNA biopesticides, such as microbial host organisms engineered to produce interfering RNA (iRNA) molecules which selectively undermine the survival of lepidopteran insects, such as agricultural pest moths and larval (caterpillar) forms thereof. Such iRNA molecules selectively inhibit the expression of a gene in a specific insect population, such as a lepidopteran population, by RNA interference. Also disclosed herein are polynucleotides, such as expression cassettes encoding iRNA molecules and facilitating integration, such as stable integration into the genome of a host cell. Further disclosed herein are compositions including the disclosed nucleotide sequences and host organisms, along with methods of using the same to control lepidopteran populations.