Fuente: WIPO "tomato" The present invention provides recombineering-editing systems using CRISPR and recombination enzymes as well as methods, vectors, nucleic acid compositions, and kits thereof. The methods and systems provide means for altering target DNA, including genomic DNA in a host cell. Specifically, the invention provides systems and compositions utilizing aptamers to bind components of the recombination-editing system such as a CAS protein or guide RNA to enhance targeting of genomic DNA in cells.