Fecha de publicación: 09/01/2025 Fuente: WIPO "tomato" The present invention demonstrates a recombinant vector for producing immunogenic substance from plants which can induce an immune response in mammals against the coronavirus disease 2019 (COVID-19). Said recombinant vector comprises at least a fragment of SARS CoV-2 receptor binding domain protein (SARS CoV-2 RBD) and a fusion protein sequence. The recombinant vector is introduced into plant cells, preferably by means of Agrobacterium sp., thereby the plant cell can express a recombinant protein which can act as an immunogenic substance. The recombinant protein of the present invention significantly demonstrates an ability to trigger immunogenicity in mammals which prevents infectious disease caused by severe acute respiratory syndrome coronavirus 2. Further, the method of inducing an immune response against SARS-CoV-2 in mammals is also provided herein. The present invention further demonstrates the use of such recombinant protein as a vaccine to prevent the coronavirus disease 2019 (COVID-19).