Fecha de publicación: -- Fuente: WIPO "tomato" The present invention relates to a process for producing microparticles comprising at least one organic active compound encapsulated by a shell of an organic wall material, which comprises



i. providing a water-immiscible liquid containing the organic active compound to be encapsulated and at least a first shell forming compound (SFC1);
ii. emulsifying the water-immiscible liquid obtained in step i. in an aqueous medium to obtain an oil-in-water (o/w) emulsion of the water-immiscible liquid in the aqueous medium;
iii. adding at least one second shell forming compound (SFC2) to the aqueous medium before or during carrying out step ii. or to the emulsion obtained in step ii., whereby an aqueous suspension of the microparticles is obtained;
where either the first shell forming compound (SFC1) or the second shell forming compound (SFC2) has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, especially 1, 2 or 3 first reactive groups (RG1) per molecule, which are selected from isocyanate groups, isothiocyanate groups, carbonyl halide groups and carboxylic anhydride groups, while the other shell forming compound has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, especially 1, 2 or 3 second reactive groups (RG2) per molecule which are selected from hydroxyl groups, thiol groups and primary amino groups, where either the first shell forming compound (SFC1) or the second shell forming compound (SFC2) has only one reactive group while the other shell forming compound has 1, 2, 3, 4, 5 or 6, in particular 1, 2, 3 or 4, especially 1, 2 or 3 reactive groups.




The present invention also relates to the microparticles obtainable by this process and to their uses.