Fecha de publicación: -- Fuente: WIPO "tomato" Described herein are systems and methods to study the emergent transcriptomic heterogeneity in cancer recurrence using a CRISPR/Cas9 modifiable lineage tracing system, mosaic analysis by dual recombinase-mediated cassette exchange (MADR) (single copy insertion) in conjunction with barcodes so that any targeted cell can be traced.