Fuente: WIPO "tomato" System(s) and/or method(s) provide for selection of a preferred guide RNA and for prediction of functional effect(s) of one or more INDELS. Such system(s) and/or method(s) can, at least partially, be computer-implemented. The system(s) and/or method(s) can include operations comprising predicting a target gene editing frequency score for each of a plurality of candidate guide RNA, predicting a functional effect of an INDELS obtained in a target plant gene, and selecting a preferred guide RNA based on the target gene editing frequency score and/or the functional effect of the INDELS.