Fuente: WIPO "tomato" A method of generating a microbial composition is disclosed. The method comprises: (a) culturing at least one food source under conditions that promote native microbial growth; (b) separating resulting microbes from the cultured food to obtain a composition comprising at least 80% of the distinct microbial species present in the microbiota of the cultured food; and (c) processing the microbes by formulating the composition for oral, endoscopic, colonoscopic or rectal administration. Microbial compositions generated thereby and uses thereof are also disclosed.