Fecha de publicación: -- Fuente: WIPO "tomato" The present disclosure provides methods for inducing tolerance to allergens or auto-antigens in a subject in need thereof comprising administering to the subject an effective amount of a composition comprising an allergen/auto-antigen polypeptide or peptide conjugated to an antibody that binds polymeric Ig receptor (plgR). In some embodiments, the composition binds to plgR-expressing Thetis cells.