Fuente: WIPO "tomato" Specific proteins catalyze specific reactions, transport specific molecules, and form specific cellular structures and changing their presence and relative abundance can be applied, for example to improve human health, animal health, crop health, carbon capture, agricultural productivity and protection, and biologic activity. However, precisely effectuating phenotypic changes and outcomes is expensive and error prone; and precisely changing protein expression in an organism has been challenging due to limited ability to control experimental factors, limitations of measurement, the exponential number of ways to affect gene expression of a protein, and limited precision and accuracy in predicting changes to expression when modifying transcription factors, promoters, and GC content. This disclosure introduces methods of gene training to help enable more direct, expedient and successful product development pipelines to digitally adjust or aim expression level of one or more proteins, such as for improving crops, carbon capture, biologics, research and development, and human health.