Fecha de publicación: -- Fuente: WIPO "tomato" Example methods for use in providing gene translation and protein expression are disclosed. One example method includes, for an input coding sequence, identifying a feature of the coding sequence as a candidate for change, based on an effect of the feature on a score for the coding sequence; selecting, by a conversion engine computing device, a codon of the coding sequence associated with the identified feature; inserting a codon equivalent for the selected codon, wherein the codon equivalent is based on a temperature associated with the coding sequence; calculating a score for the coding sequence with the codon equivalent and a score for the input coding sequence; and advancing the coding sequence with the codon equivalent to a next iteration when the score for the coding sequence with the codon equivalent indicates an enhancement relative to the score of the input coding sequence.