Fuente: WIPO "tomato" A system for determining a prescriptive therapy instruction set may include a computing device configured to receive a first subject prescription datum associated with a first subject; receive a first subject tolerance datum associated with the first subject; determine a prescriptive therapy instruction set by training a prescriptive therapy instruction set machine learning model on a training dataset including a plurality of example subject prescription data and subject tolerance data as inputs correlated to a plurality of example prescriptive therapy instruction sets as outputs; and generating the prescriptive therapy instruction set as a function of the subject prescription datum and the subject tolerance datum using the trained prescriptive therapy instruction set machine learning model; receive a second subject tolerance datum associated with the first subject; and retrain the prescriptive therapy instruction set machine learning model as a function of the second subject tolerance datum.