Fecha de publicación: -- Fuente: WIPO "tomato" Disclosed are useful compositions and methods for enhancing cell transduction efficiency of a nanocarrier comprising a genetic payload that encodes a therapeutic agent. Embodiments of the present disclosure provide kits for transducing epithelial stem cells in a subject in need thereof. The present disclosure also provides methods of treating diseases of skin and mucous membranes in a subject using the disclosed compositions.