Fuente: WIPO "tomato" The present invention refers to lipid-based nanoparticles characterized by specific proteins and miRNAs that confer therapeutic capacity to these nanoparticles. The present invention also refers to the clinical applications of these nanoparticles for the treatment of ischemic heart diseases. Pharmaceutical compositions comprising one or more of these lipid nanoparticles are also contemplated. Finally, the use of the nanoparticles as a nanocarriers, nanovectors and/or nanocapsules for the release and/or encapsulation of molecules is also referred.