Fuente: WIPO "tomato" The technology relates in part to antibodies or antigen-binding fragments thereof that bind one or more members of the KIR family of proteins (e.g., KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5, KIR2DS1, KIR2DS2, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, and/or KIR3DL3) or portions thereof, as well as methods, systems and kits for detection of KIR. In certain aspects, the technology relates to antibodies or antigen binding fragments thereof for use in determining levels of KIR in a sample containing or suspected of containing KIR. In some aspects, the technology relates to antibodies or antigen-binding fragments thereof for use in diagnosing or treating an individual with or suspected of having a disease or disorder associated with KIR.