Fecha de publicación: -- Fuente: WIPO "tomato" Provided are compositions and methods for treating diseases associated with aberrant glycosylation of cell surface molecules and expression of tumor-associated carbohydrate antigens (TACA). Also provided are bi-specific fusion proteins and chimeric antigen receptors (CARs) specific to tumor-associated carbohydrate antigens (TACA-CARs), vectors encoding the TACA-bi-specific fusion proteins and CARs, and recombinant cells comprising the TACA-bi-specific fusion proteins and CARs.