Fuente: WIPO "tomato" The present disclosure relates to cyclases from filamentous fungi that mediate the production of indole diterpenes bearing a tetrahydropyran (THP) ring and to isolated host cells that heterologously express such cyclases. Also disclosed are biosynthetic gene clusters encoding PaxA and PaxA equivalent cyclases that direct formation of IDTs comprising THP rings in isolated host cells, preferably isolated fungal cells, and methods of making and use.