Fuente:
WIPO "tomato"
Compositions and methods for forming dilute compositions suitable for administration to or ingestion by insect pollinators such as honeybees. Provided herein are concentrated formulations containing one or more flavonoids e.g., rutin, and a solvent e.g., sodium bicarbonate. The flavonoids are present in the composition in an effective amount to protect against impairment of a cognitive and/or immune function of the insect pollinator, and are more soluble in the solvent than in a 1M aqueous sucrose solution. Also provided are dilute compositions formed from the concentrated formulations that are suitable for administration to or ingestion by insect pollinators to protect them against the neurocognitive effects of pesticides. Also provided are methods of protecting the cognitive function of an insect pollinator from a pesticide. The methods generally include applying or placing a dilute composition in a hive located in an area that is occupied by one or more insect pollinators.