Fuente: WIPO "tomato" Described herein is a nucleic acid comprising a sequence encoding an epigenetic effector fusion comprising at least two epigenetic effectors. Described herein is an epigenetic editing system comprising any nucleic acid described herein and a nucleic acid encoding a gRNA comprising an RNA aptamer sequence that binds to the RNA binding protein. Described herein is a method of regulating gene expression, the method comprising introducing into a cell: any of the epigenetic modulation system described herein.