Fuente: WIPO "tomato" The present disclosure relates to synthetic RNAs comprising a piRNA sequence and a target sequence for a target gene of interest, vectors comprising the synthetic RNA, and genetically modified cells comprising the synthetic RNAs. Compositions and kits comprising the same are provided, as well as methods of regulating the expression of a target gene in an organism for pesticide treatment, control, or management. Also, transgenic plants containing the above-mentioned synthetic RNAs are made.