Fuente: WIPO "tomato" In general, disclosed herein are artificial transcription factors (ATFs) and methods thereof. Methods disclosed herein may include administering to a subject in need thereof an ATF disclosed herein. ATFs disclosed herein may include a DNA-binding domain and an activator domain. The DNA-binding domain may include from about 2 to about 8 zinc finger proteins. The zinc finger proteins may bind to a target site including SEQ ID NOs: 5-28, 30-34, 41-66, and/or 67-79.