Fuente:
WIPO "tomato"
The present disclosure provides compositions related to the selective binding of both endogenous dystrophin proteins (e.g., full length dystrophin), which are relevant for their role in numerous genetic neuromuscular disorders, including Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), and microdystrophin proteins (e.g., delandistrogene moxeparvovec-rokl), which are used in the treatment of genetic neuromuscular disorders. The disclosure includes proteins, antibodies and/or fragments thereof and associated polynucleotide constructs. The disclosure further provides methods for manufacturing said compositions and other uses for the same.