Fecha de publicación: -- Fuente: WIPO "tomato" An autophagy-inducing, fasting-mimicking diet (FMD) is provided as multi-day dietary regimens, compositions, foodstuffs, and kits configured to induce autophagy and improve metabolic health while permitting controlled nutrient intake. The regimens include a first-day formulation providing about 300 to 1600 kcal and at least one subsequent-day formulation providing about 200 to 1000 kcal, with defined ranges of proteins, fats, and carbohydrates selected to sustain fasting-like metabolism and autophagic flux. In certain embodiments, a five-day regimen provides about 1100 kcal on Day 1 and about 720 kcal on Days 2-5. The compositions may be provided as nutrition bars, soups, snacks, beverages, teas, and supplements assembled into pre-portioned daily kits. Clinical evaluation demonstrated increased ketone bodies, improved metabolic markers, and increased autophagic flux, supporting use of the regimens to promote metabolic health and reduce risks associated with age-related diseases.