Fecha de publicación: -- Fuente: WIPO "tomato" Described here are devices and systems that allow for scalable on-chip screening of bioagents, chemicals, or combinatorial cellular libraries and use thereof, as well as methods of molding the devices. Bioagents or chemical samples are prepared to generate droplets. The devices described herein comprise arrays of microwells capable of receiving one or more individual droplets. The droplets are then transferred and pooled to be loaded to an MCSD described herein. Further provided herein are automated systems for high throughput screening comprising various components, such as a device described herein, a loading apparatus, one or more robot arms configured for automated loading and merging of droplets and automated transferring samples, an automated incubator and a controller. Also described here are methods for screening using the devices and systems described herein.