Fuente: WIPO "tomato" The present disclosure relates to lipid delivery particles for delivery of payloads across cell membrane into the target cell. The present disclosure relates to lipid delivery particles comprising a lipid membrane on the external side and a chimeric protein in the core comprising a transmembrane domain, a payload, and a cleavable linker cleavable by protease expressed in the target cells. The systems and methods described herein provide for: the ability to produce the lipid delivery particles and the ability to delivery payloads such as proteins and small molecules into the target cells.