Fuente: WIPO "tomato" Described herein is a method of treating, ameliorating and/or preventing a neurodegenerative disease in a subject. The method includes administer to the subject a compound that reverses, ameliorates, and/or prevents a formation or enlargement of an axonal spheroid in a neuron of the subject. Also described herein is a method of reversing, ameliorating, and/or preventing a formation or enlargement of an axonal spheroid, as well as a compound for treating, ameliorating and/or preventing a neurodegenerative disease in a subject.