Fecha de publicación: 16/01/2025 Fuente: WIPO "tomato" The present disclosure relates to novel polynucleotide sequences, constructs, and cell hosts for expressing the same, and compositions comprising the same. The disclosure further relates to methods for using the novel polynucleotide sequences, constructs, cell hosts, and compositions. In some embodiments, a first polynucleotide encodes a polypeptide capable of having natural killer (NK) cell inhibiting activity; and a second polynucleotide encodes a polypeptide capable of inducing an immune response or encoding a naturally endogenously produced protein.