Fuente: WIPO "tomato" Compositions and methods for targeting pre-determined DNA or RNA sequences in plant pests are provided. The methods result in the targeted elimination of plant pests that comprise the pre-determined DNA or RNA sequence(s). Compositions comprise a Cas12a2 protein, or a polynucleotide encoding the same, and at least one guide polynucleotide, or a polynucleotide encoding the same, wherein each guide polynucleotide comprises a portion complementary to a pre-determined target sequence of a plant pest. Methods to use these compositions to selectively target and eliminate plant pests that harbor the targeted DNA or RNA sequence(s) are described herein.