Fecha de publicación: -- Fuente: WIPO "tomato" The current invention relates to a pharmaceutical composition comprising a therapeutically active amount of a soluble antibody or antibody fragment, or a nucleic acid encoding for said soluble antibody or antibody fragment, for use in the treatment and/or prevention of epilepsy or seizure in a patient. Said antibody or antibody fragment is a modulator of the Wnt7 signaling pathway, preferably an agonist of the Wnt7 signaling pathway, and said antibody or antibody fragment comprises one or more Lipoprotein Receptor-related Protein (LRP) binding domains, and further one or more Gpr124 and/or Reck binding domains.