Fuente: WIPO "tomato" The present disclosure relates to a CD3-targeting antibody and use thereof. Specifically, the present disclosure provides an antibody or antigen-binding fragment thereof that specifically binds to CD3, a nucleic acid encoding the antibody or antigen-binding fragment thereof, a nucleic acid vector comprising the nucleic acid, a host cell comprising the nucleic acid or nucleic acid vector, a pharmaceutical composition comprising the aforementioned substances, and a preparation method therefor and use thereof.