ANTIFUNGAL POLYENE MACROLIDES

Fuente: WIPO "tomato"
The disclosure provides a polyene. The polyene comprises two sugar moieties and/or is modified in an exocyclic carboxylic acid position, or is a pharmaceutically acceptable salt, solvate, tautomeric form or polymorphic form thereof. In some embodiments, the polyene is a compound of formula I. The disclosure extends to pharmaceutical and agrochemical compositions, preservatives and foodstuffs comprising the polyene. The disclosure also extends to the polyene or pharmaceutical composition for use as a medicament, for use in treating, preventing or ameliorating an infection or a prion disease and methods of treating a disease in a plant or a mushroom using the polyene. The disclosure further provides a method of producing a polyene comprising a sugar moiety and/or a modification at an exocyclic carboxylic acid thereon. Finally, the disclosure also extends to a recombinant organism or cell expressing a glycosyltransferase enzyme or an amidotransferase enzyme.