Fecha de publicación: 15/01/2025 Fuente: WIPO "tomato" The present invention relates to an antibody, or an antigen binding fragment thereof, and to the CAR T-cell comprising the antigen binding fragment of said antibody. The invention also discloses to the polynucleotides encoding said antibody, the vector, the cells, the antibody-drug conjugate, and the composition comprising the antibody, the antigen binding fragment thereof, and/or to the CAR T-cell, all of them being useful in the treatment and/or prevention of leukemia, more preferably T-cell acute lymphoblastic leukemia (T-ALL), still more preferably T-ALL pre-TCR+, in a subject.