Fecha de publicación: -- Fuente: WIPO "tomato" The present invention generally relates to recombinant polypeptides capable of regulating actin remodelling. In particular, the polypeptides disclosed herein are selective for ADP-actin and may modulate ADP-actin remodelling under energy starvation conditions. The recombinant polypeptides of the present invention are also suitable for use in detecting ADP-actin activity in vitro or in living cells, in drug screening, in therapeutic approaches and for the treatment of actin-associated diseases.